Saas Fee Declaration

In the June 1992, I helped organize a meeting of seventeen of the world’s leading scientists at the village of Saas Fee, Switzerland, where the air is crystal clear and the skiing is magnificent, even in June. In that idyllic environment, this group of researchers, who have dedicated their professional lives to studying antioxidant and free radical biology, examined and celebrated some startling new discoveries about the role of antioxidants and free radicals in the prevention and treatment of many chronic and degenerative diseases.


At the Saas Fee meeting, we studied the overwhelming body of evidence that shows that if used strategically, antioxidants can help maintain our health and vigor well into our seventh, eighth,  and ninth decades, and perhaps even longer.  With great excitement, we listened as our colleagues reported on groundbreaking research that will profoundly affect the way medicine will be practiced in the twenty-first century, which is right around the corner.  Eager to generate grater scientific and public interest in the field of antioxidants, eight of the conference participants (including me ) composed and affixed our signatures to a document we called “The Saas Fee Declaration .” The essence of the declaration is that the scientific evidence that antioxidants play a pivotal role in maintaining health and preventing disease is now overwhelming and incontrovertible , and that scientists,  health-care professionals, and the government have a duty to inform the public about this.


After the meeting, we circulated “the Saas Fee Declaration ” among our colleagues around the world, and it has since been signed by hundreds of others. In fact, the response of the international scientific community has been so overwhelming that we’ve run out of room for signatures! I would like to share the “the Saas Fee Declaration ” with you here so that you can begin to understand what the excitement is all about.

Saas Fee Declaration



1.       The intensive research on free radicals of the past fifteen years by scientists worldwide has led to the statement in 1992 that antioxidant nutrients may have major significance in the prevention of a number of disease. These include cardiovascular and cerebrovascular disease, some forms of cancer, and several other disorders, many of which may be age-related.


2.       There is now general agreement that there is a need for further work at the fundamental scientific level, as well as in large-scale randomized trials and in clinical medicine, which can be expected to lead to more precise information being made available.


3.       The major objective of this work is the prevention of disease.  This maybe achieved by the use of antioxidants, which are natural physiological substances. The strategy should be to achieve optimal intakes of these antioxidant nutrients as part of preventive medicine.


4.       It is quite clear that many environmental sources of free radicals exist, such as ozone, sunlight,  and other forms of radiation , smog,  dust,  and other atmospheric pollutants. The optimal intake of antioxidants provides a preventive measure against these hazards.


5.       There is a great need for improvement in public awareness of the potential preventive benefits of antioxidant nutrient intake.  There is overwhelming evidence that the antioxidant nutrients such as vitamin E, vitamin C, carotenoids, alpha-lipoic acid,  and others are safe even at very high levels of intake.


6.       Moreover, there is now substantial agreement that governmental agencies, health professionals, and the media should promote information transfer to the general public, particularly when evidence exists that benefits for human health and public expenditure are over whelming.



                                    Igor Afanas ev, Moscow

Julie E. Buring, Harvest 

Anthony T. Diplock, London

Charles H. hennekens, Harvard

Bodo Kuklinski, Rostov

Mathilde Maiorino, Padua

Lester Packer, Berkeley

Mulchand S. Patel, Cleveland

Karlheina Schmidt, Tubingen 


1992年六月,我协助组织一场由世界17位著名科学家在瑞士Saas Fee召开的会议,那里的空气清新,即使在六月滑雪运动也很壮观。在那田园诗般的环境中,把毕生精力置身于抗氧化和自由基生物研究的学者们,审查和庆祝抗氧化剂和自由基在预防和治疗许多慢性疾病方面令人惊奇的新发现。

Saas Fee会议上,我们研究大量证据表明,如果有策略地使用抗氧化剂,能使我们保持健康与活力,并且能保持旺盛的精力直到70岁、80岁、90岁或者更加长寿。令人兴奋的是,我们所听到的同行们突破性的研究报告,将深刻影响21世纪遍布世界每一角落行医用药习惯。为了抗氧化领域产生更大的公共利益,8位与会者(包括本人)联合签署了一份文件“萨斯费城宣言”。宣言的主旨是:科学证据显示,抗氧化剂在维持健康和预防疾病方面扮演了举足轻重的角色,政府机构、科学家和保健专业人员有义务把这些知识推广和普及给大众。










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